CELL DEATH DIS 润色咨询. Cell death and diseases A) Neurodegenrative diseases related to cell death, they are the most common form of diseases caused by an increase in cell death, examples are: 1) Parkinson's Disease (PD): A neurodegenerative disorder of the central nervous sysytem. Balancing cell death and survival is essential for normal development and homeostasis and for preventing diseases, especially cancer. Pioneering new research has unraveled distinct roles and cross talk of caspases in the regulation of programmed cell death, inflammation, and innate immune responses. Cell adhesion and migration can also be a pathogenic process in a variety of diseases. Crosstalk between autophagy and apoptosis has emerged as a pivotal factor for the regulation of mtDNA release, cell’s fate, and inflammation. Journal of Cell Death is an international, peer reviewed, open access journal that focuses on all types and aspects of cell death, both natural and pathological, and at both the basic and applied levels. Cell Death & Disease. “Cell Signaling and Regulated Cell Death” section of Cells aims to stimulate research that focuses on the understanding of cell signaling and cell death pathways in evolution, development, physiology, and disease. 285, 1754–1764 (2010). They play important roles in cellular bioenergetics, control intracellular Ca2+ homeostasis, and participate in key metabolic pathways. Tumor metastasis, for example, develops based on the high potential of tumor cells to both migrate and adhere. Journal Citation Reports (Clarivate Analytics, 2020) 5-Year Impact Factor: 3.622 ℹ Five-Year Impact Factor: 2019: 3.622 出版周期：Monthly 自引率：2.8% 审稿周期：平均1.94月 Brought to you by the editorial team of Cell Death & Differentiation, Cell Death & Disease is a peer-reviewed online journal in the field of translational cell death. However, our previous evidence has demonstrated that simvastatin leads to cytotoxicity in NSC34-hSOD1G93A cells by aggravating the impairment of autophagic flux, but the role … Using flow cytometry, functional assays and RNA sequencing techniques we identify liver‐resident CXCR6+ NK cells to have reduced functionality in comparison to CD49a NK cells. Statins, as inhibitors of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase, are used as drugs for treatment for a variety of disease such as ischemic diseases, neurodegenerative diseases, cancer, and inflammation. It is now also accepting articles in a new area: cancer metabolism. In-depth understanding of these mechanisms is essential to foster the development of precise therapeutic targets to treat autoinflammatory disorders, infectious diseases, and cancer. It results from diverse causes, including … Cell Death and Disease is an open-access journal published by Nature Publishing Group. DOAJ is a community-curated online directory that indexes and provides access to high quality, open access, peer-reviewed journals. In the past few years, there has been considerable advancement in our understanding of cell death, including the discovery of a series of highly regulated molecular pathways implicated in determining whether a cell will survive or succumb. The aim is to build a community of authors and readers to discuss the latest research and develop new ideas and research directions. Regulated cell death is a major mechanism to eliminate damaged, infected, or superfluous cells. in 2014 and 2015. Aging & Disease (A&D) is a peer reviewed, open access online journal that aspires to publish novel and high-impact findings on central issues pertaining to the biology of aging, pathophysiology of age-related diseases, and innovative therapies for diseases afflicting the elderly population. The mechanisms of retinal cell death in AMD are an area of active investigation; previous studies have proposed several types of cell death as major mechanisms. Recent evidence has indicated that the caspase family of cysteine proteases is a central effector in apoptotic cell death and is absolutely responsible for many of the morphological features of apoptosis. Impact Factor: 2016 Journal Impact Factor is the ratio of the number of citations achieved in the year 2016 based on Google Search and Google Scholar Citations to the total number of articles published in the last two years i.e. Fifteen years on, it is still the best-reputed journal in the field, with an impact factor to match. About this journal. The 2018 Gordon Research Conference on Cell Death will foster unencumbered scientific exchange, focusing on mechanisms that specify cell death in normal development and in various human pathologies. Bioxbio.com includes the journal factors, ISSN, number of articles and other detailed information of over 11000 journals in different fields. Strengthened adhesion between immune cells and nerves or epithelia often results in exacerbation of inflammation and degeneration of nerves or epithelia. Chem. Cell Death & Disease | Citations: 5,309 | Read 1100 articles with impact on ResearchGate, the professional network for scientists. Cells runs special issues to create collections of papers on specific topics. Gastric cancer (GC) is the fifth most common malignancy and third leading cause of cancer-related death worldwide with the annual death rate in … Impact Factor: 4.803 ℹ Impact Factor: 2019: 4.803 The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. Whether or not cellular stress triggers cell death or cell survival programs is determined by a set of different factors, among them the initial stress stimulus, cell type, and environmental factors. J. Biol. Following cell death-triggering stressors, mtDNA can be released from the cell and ignite inflammation via several pathways. Ferroptosis, a newly discovered programmed cell death pathway, has been associated with the pathogenesis of several neurodegenerative diseases. Journal Citation Reports (Clarivate Analytics, 2020) 出版年份：2010 年文章数：884 投稿命中率：37.5%. Dual positive CXCR6+CD49a+ NK cells more closely resemble the single positive CD49a+ population. As the second most common age related neurodegenerative disease after Alzheimer's disease, the health, social and economic impact resulting from Parkinson's disease will continue to increase alongside the longevity of the population. Previously, apoptosis was thought to be the only regulated cell death mechanism; however, new modalities of caspase-independent regulated cell death have been identified, including necroptosis, pyroptosis, and autophagic cell death. Many diseases are frequently associated with excessive, reduced or inappropriate cell death. Mutations in genes involved in mitochondrial quality control cause a myriad of neurodegenerative diseases. The aim of this study is to illustrate the impact of tremor induction on the expression of factors mediating the cell surface death receptor–dependent apoptosis.
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